Isuggest switching Empty Hand from SHIFT to MOUSE 1, and switching High Profile to SHIFT instead of MOUSE 1. This is very useful. Based in what I use for AC1 I would try WASD for movement, Shift for high profile, arrows for head/hands/legs, mouse for camera, tab for lock on, ctrl for weapon wheel, numbers for weapons quick selection, caps lock
Withan Xbox 360 controller, AC controls like a dream. It takes a little getting used to, but when you do actually get used to it, it's very intuitive and makes the control just seem so fluid - you think it and it happens. The Assassin's Creed games on PC also have terrible mouse controls, especially Brotherhood. aACm2Ly.